Book Name: [PDF] Advances in Chromatography, Volume 53 by Eli Grushka and Nelu Grinberg
Category: Analytical Chemistry
Language: English
Format: PDF
Free Download: Available

Advances in Chromatography, Volume 53 by Eli Grushka and Nelu Grinberg : Since the beginning of chiral chromatography in 1930s, researchers have taken an interest in mechanisms responsible for the resolution of racemic mixtures on optically active adsorbents. It was understood that behind this phenomenon lies “the asymmetric character of the adsorbing surface, which causes it to react differently towards the enantiomorphous components of the racemic compound” [1]. From this, it immediately followed that the stereochemical configuration of enantiomers was the major factor affecting their interaction with the chiral surface. Hence, a study of the dependence of the adsorption affinity on the spatial configuration of solutes seemed to be a key step in the elucidation of the nature of enantioseparation [2]. This fundamental program of research took impulse after the famous publication by Dalgliesh [3], who attempted to explain the separation of enantiomers of amino acids on cellulose based on spatial considerations. At that time, there were no tools to investigate interactions between a solute and an adsorbent on the molecular level, so researchers used indirect integral characteristics, such as retention factor (k′) and enantioselectivity (α), to elucidate mechanisms resulting in different migration velocities of optical antipodes in a chiral media. This approach is called macroscopic because it disregards the molecular structure of the system under investigation and operates with quantities averaged (in thermodynamic sense) over large ensembles of molecules and over a certain period of time. Tremendous improvements in molecular techniques made in the past three decades, in particular, in molecular modeling [4,5] as well as in spectrometric methods (NMR, FT-IR, VCD, etc.) and x-ray crystallography [6] allowed researchers to study solute– selector binding at the microscopic level.
Download to Read more….

Advances in Chromatography, Volume 53 by Eli Grushka and Nelu Grinberg

Title: Advances in Chromatography
Editor: Eli Grushka
Nelu Grinberg
Volume: 53rd
Publisher: CRC Press
Length: 370 pages
Size: 14.7 MB
Language: English


Chapter 1. Solute-stationary phase interaction in chiral chromatography / Leonid D. Asnin, Alberto Cavazzini, and Nicola Marchetti —
chapter 2. The role of chromatography in alzheimer’s disease drug discovery / Jessica Fiori, Angela De Simone, Marina Naldi, and Vincenza Andrisano —
chapter 3. Characterization of the kinetic performance of silica monolithic columns for reversed-phase chromatography separations / Gert Desmet, Sander Deridder, and Deirdre Cabooter —
chapter 4. Recent advances in the characterization and analysis of therapeutic oligonucleotides by analytical separation methods coupling with mass spectrometry / Su Pan and Yueer Shi —
chapter 5. Uncertainty evaluation in chromatography / Veronika R. Meyer —
chapter 6. Comprehensive two-dimensional hydrophilic interaction Chromatography x reversed-phase liquid chromatography (HILIC x RP-LC) : theory, practice, and applications / André de Villiers and Kathithileni Martha Kalili —
chapter 7. Sample preparation for thin layer chromatography / Mieczysław Sajewicz, Teresa Kowalska, and Joseph Sherma —
chapter 8. Modeling of HPLC methods using QbD principles in HPLC / Imre Molnár, Hans-Jürgen Rieger, and Robert Kormány.


Advances in chromatography. Volume 53

Author(s): Grinberg, Nelu; Grushka, Eli

Publisher: CRC Press, Year: 2017

ISBN: 978-1-4987-2678-8



Buy From Amazon

Related More Books
Thanks For Visiting Our Website To Support Us, Keep Share On Social Media.