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[PDF] Jawetz Melnick & Adelberg’s Medical Microbiology 28 E

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    Jawetz Melnick & Adelberg’s Medical Microbiology 28 E By Stefan Riedel, Stephen A. Morse, Timothy A. Mietzner, Steve Miller

     

    Jawetz Melnick & Adelbergs Medical Microbiology 28 E is biology book by Stefan Riedel, Stephen A. Morse, Timothy A. Mietzner, Steve Miller, published in 2019.

    Since 1954, Jawetz, Melnick & Adelberg’s Medical Microbiology has been hailed by students, instructors, and clinicians as the single-best resource for understanding the roles microorganisms play in human health and illness.

    Concise and fully up to date, this trusted classic links fundamental principles with the diagnosis and treatment of microbial infections. Along with brief descriptions of each organism, you will find vital perspectives on pathogenesis, diagnostic laboratory tests, clinical findings, treatment, and epidemiology. The book also includes an entire chapter of case studies that focuses on differential diagnosis and management of microbial infections.

    Here’s why Jawetz, Melnick & Adelberg’s Medical Microbiology is essential for USMLE® review:

    • 640+ USMLE-style review questions
    • 350+ illustrations
    • 140+ tables
    • 22 case studies to sharpen your differential diagnosis and management skills
    • An easy-to-access list of medically important microorganisms
    • Coverage that reflects the latest techniques in laboratory and diagnostic technologies
    • Full-color images and micrographs
    • Chapter-ending summaries
    • Chapter concept check

     

    Table of contents :

    Cover……Page 1
    Title Page……Page 2
    Copyright Page……Page 3
    Index……Page 0
    Preface……Page 4
    Biologic Principles Illustrated by Microbiology……Page 6
    Viruses……Page 7
    Prions……Page 8
    Prokaryotes……Page 9
    Protists……Page 12
    Review Questions……Page 14
    Optical Methods……Page 16
    Eukaryotic Cell Structure……Page 18
    Prokaryotic Cell Structure……Page 21
    Staining……Page 43
    Morphologic Changes During Growth……Page 44
    Review Questions……Page 45
    Criteria for Identification of Bacteria……Page 48
    Classification Systems……Page 51
    Description of the Major Categories and Groups of Bacteria……Page 53
    Nonculture Methods for the Identification of Pathogenic Microorganisms……Page 57
    Review Questions……Page 58
    The Meaning of Growth……Page 60
    Exponential Growth……Page 61
    The Growth Curve in Batch Culture……Page 62
    Growth in Biofilms……Page 63
    Strategies to Control Bacteria at the Environmental Level……Page 64
    General Mechanisms of Biocide Action……Page 66
    Specific Actions of Selected Biocides……Page 68
    Relationship of Biocide Concentration and Time on Antimicrobial Killing……Page 69
    Key Concepts……Page 70
    Review Questions……Page 71
    Sources of Metabolic Energy……Page 74
    Nutrition……Page 75
    Environmental Factors Affecting Growth……Page 76
    Cultivation Methods……Page 79
    Review Questions……Page 83
    Focal Metabolites and Their Interconversion……Page 86
    Assimilatory Pathways……Page 89
    Biosynthetic Pathways……Page 97
    Patterns of Microbial Energy-Yielding Metabolism……Page 100
    Regulation of Metabolic Pathways……Page 106
    Review Questions……Page 108
    Nucleic Acids and Their Organization in Eukaryotic, Prokaryotic, and Viral Genomes……Page 110
    Replication……Page 115
    Transfer of DNA……Page 116
    Mutation and Gene Rearrangement……Page 119
    Gene Expression……Page 120
    Genetic Engineering……Page 124
    Characterization of Cloned DNA……Page 125
    Analysis of DNA, RNA, or Protein-Expressing Clones……Page 128
    Manipulation of Cloned DNA……Page 129
    Review Questions……Page 130
    Innate Immunity……Page 132
    Adaptive Immunity……Page 136
    Complement……Page 146
    Cytokines……Page 149
    Hypersensitivity……Page 151
    Tumor Immunology……Page 153
    Clinical Immunology Laboratory (Diagnostic Testing)……Page 154
    Chapter Summary……Page 155
    Review Questions……Page 156
    9. Pathogenesis of Bacterial Infection……Page 160
    Identifying Bacteria That Cause Disease……Page 161
    Transmission of Infection……Page 162
    Genomics and Bacterial Pathogenicity……Page 163
    Bacterial Virulence Factors……Page 164
    Chapter Summary……Page 172
    Review Questions……Page 173
    Role of the Resident Microbiota……Page 176
    Normal Microbiota of the Skin……Page 177
    Normal Microbiota of the Mouth and Upper Respiratory Tract……Page 179
    Normal Microbiota of the Placenta and Uterus……Page 183
    Review Questions……Page 184
    Bacillus anthracis……Page 188
    Clostridium species……Page 191
    Clostridium botulinum……Page 192
    Clostridium tetani……Page 193
    Clostridia That Produce Invasive Infections……Page 195
    Clostridium difficile and Diarrheal Disease……Page 196
    Review Questions……Page 197
    12. Aerobic Non–Spore-Forming Gram- Positive Bacilli: Corynebacterium, Listeria, Erysipelothrix, Nocardia, and Related Pathogens……Page 200
    Corynebacterium diphtheriae……Page 201
    Listeria monocytogenes……Page 204
    Rhodococcus equi……Page 206
    Nocardiosis……Page 207
    Review Questions……Page 208
    13. The Staphylococci……Page 210
    Review Questions……Page 217
    Classification of Streptococci……Page 220
    Streptococcus pyogenes……Page 222
    Groups C and G……Page 227
    Viridans Streptococci……Page 228
    Streptococcus pneumoniae……Page 229
    Enterococci……Page 233
    Other Catalase-Negative Gram-Positive Cocci……Page 235
    Review Questions……Page 237
    Classification……Page 240
    Diseases Caused by Enterobacteriaceae Other Than Salmonella and Shigella……Page 243
    The Shigellae……Page 247
    The Salmonellae……Page 250
    Review Questions……Page 255
    Pseudomonas aeruginosa……Page 258
    Burkholderia pseudomallei and Burkholderia mallei……Page 261
    Burkholderia cepacia Complex……Page 262
    Acinetobacter……Page 263
    Review Questions……Page 264
    Vibrio cholerae……Page 266
    Vibrio parahaemolyticus and Vibrio vulnificus……Page 270
    Aeromonas species……Page 271
    Campylobacter jejuni……Page 272
    Helicobacter pylori……Page 273
    Review Questions……Page 277
    Haemophilus influenzae……Page 280
    Haemophilus aegypticus……Page 282
    Bordetella pertussis……Page 283
    Bordetella bronchiseptica……Page 285
    Francisella tularensis and Tularemia……Page 288
    Review Questions……Page 290
    Yersinia pestis and Plague……Page 294
    Yersinia enterocolitica and Yersinia pseudotuberculosis……Page 296
    Review Questions……Page 298
    Neisseria gonorrhoeae……Page 300
    Neisseria meningitidis……Page 306
    Other Neisseriae……Page 308
    Review Questions……Page 309
    Physiology and Growth Conditions for Anaerobes……Page 312
    Anaerobic Bacteria Found in Human Infections……Page 313
    Gardnerella vaginalis……Page 314
    Pathogenesis of Anaerobic Infections……Page 315
    Diagnosis of Anaerobic Infections……Page 316
    Review Questions……Page 317
    Legionella pneumophila and Other Legionellae……Page 320
    Bartonella……Page 323
    Whipple Disease……Page 325
    Review Questions……Page 326
    Mycobacterium tuberculosis……Page 328
    Other Mycobacterium……Page 337
    Mycobacterium leprae……Page 339
    Review Questions……Page 340
    Treponema pallidum and Syphilis……Page 344
    Borrelia species and Relapsing Fever……Page 348
    Borrelia burgdorferi and Lyme Disease……Page 349
    Leptospira and Leptospirosis……Page 351
    Review Questions……Page 353
    Mycoplasmas……Page 356
    Mycoplasma pneumoniae and Atypical Pneumonias……Page 358
    Chapter Summary……Page 359
    Review Questions……Page 360
    Rickettsia and Orientia……Page 362
    Ehrlichia and Anaplasma……Page 366
    Coxiella burnetii……Page 367
    Review Questions……Page 369
    27. Chlamydia spp……Page 372
    Trachoma……Page 375
    Chlamydia trachomatis Genital Infections and Inclusion Conjunctivitis……Page 376
    Lymphogranuloma Venereum……Page 377
    Chlamydia pneumoniae and Respiratory Infections……Page 378
    Chlamydia psittaci and Psittacosis……Page 379
    Review Questions……Page 381
    Inhibition of Cell Wall Synthesis……Page 384
    Inhibition/Alteration of Cell Membrane Function……Page 386
    Inhibition of Protein Synthesis……Page 387
    Inhibition of Nucleic Acid Synthesis……Page 388
    Origin of Drug Resistance……Page 389
    Clinical Implications of Drug Resistance……Page 390
    Measurement of Antimicrobial Activity……Page 392
    Drug–Pathogen Relationships……Page 393
    Host–Pathogen Relationships……Page 394
    Antimicrobial Drugs Used in Combination……Page 395
    Antimicrobial Chemoprophylaxis……Page 396
    Penicillins……Page 398
    Cephalosporins……Page 404
    Tetracyclines……Page 406
    Chloramphenicol……Page 407
    Macrolides……Page 408
    Glycopeptides, Lipopeptides, Lipoglycopeptides……Page 409
    Polymyxins……Page 410
    Aminoglycosides……Page 411
    Quinolones……Page 412
    Sulfonamides and Trimethoprim……Page 413
    Drugs Used Primarily to Treat Mycobacterial Infections……Page 414
    Review Questions……Page 416
    Terms and Definitions in Virology……Page 418
    Classification of Viruses……Page 419
    Principles of Virus Structure……Page 425
    Chemical Composition of Viruses……Page 426
    Cultivation and Detection of Viruses……Page 428
    Purification and Identification of Viruses……Page 429
    Reaction to Physical and Chemical Agents……Page 430
    Replication of Viruses: An Overview……Page 431
    Genetics of Animal Viruses……Page 435
    Natural History (Ecology) and Modes of Transmission of Viruses……Page 437
    Review Questions……Page 439
    Pathogenesis of Viral Diseases……Page 442
    Prevention and Treatment of Viral Infections……Page 454
    Review Questions……Page 459
    Parvovirus Infections in Humans……Page 462
    Review Questions……Page 466
    Properties of Adenoviruses……Page 468
    Adenovirus Infections in Humans……Page 472
    Review Questions……Page 475
    Properties of Herpesviruses……Page 478
    Herpes Simplex Viruses……Page 481
    Varicella-Zoster Virus……Page 487
    Epstein-Barr Virus……Page 491
    Cytomegalovirus……Page 494
    Human Herpesvirus 6……Page 498
    Herpes B Virus……Page 499
    Review Questions……Page 500
    Properties of Poxviruses……Page 504
    Poxvirus Infections in Humans: Vaccinia and Variola……Page 507
    Molluscum Contagiosum……Page 511
    Tanapox and Y aba Monkey Tumor Poxvirus Infections……Page 513
    Review Questions……Page 514
    Properties of Hepatitis Viruses……Page 516
    Hepatitis Virus Infections in Humans……Page 521
    Chapter Summary……Page 532
    Review Questions……Page 533
    Properties of Picornaviruses……Page 536
    Polioviruses……Page 537
    Coxsackieviruses……Page 542
    Other Enteroviruses……Page 545
    Rhinoviruses……Page 546
    Foot-and-Mouth Disease (Aphthovirus of Cattle)……Page 548
    Review Questions……Page 549
    Reoviruses and Rotaviruses……Page 552
    Rotaviruses……Page 553
    Reoviruses……Page 556
    Caliciviruses……Page 557
    Astroviruses……Page 559
    Review Questions……Page 560
    Human Arbovirus Infections……Page 562
    Togavirus and Flavivirus Encephalitis……Page 564
    Yellow Fever Virus……Page 572
    Dengue Virus……Page 574
    Bunyavirus Encephalitis Viruses……Page 575
    Severe Fever with Thrombocytopenia Syndrome Virus……Page 576
    Bunyavirus Diseases……Page 577
    Arenavirus Diseases……Page 579
    Filovirus Diseases……Page 581
    Review Questions……Page 583
    Properties of Orthomyxoviruses……Page 586
    Influenza Virus Infections in Humans……Page 591
    Review Questions……Page 597
    Properties of Paramyxoviruses……Page 600
    Parainfluenza Virus Infections……Page 604
    Respiratory Syncytial Virus Infections……Page 607
    Human Metapneumovirus Infections……Page 609
    Mumps Virus Infections……Page 610
    Measles (Rubeola) Virus Infections……Page 612
    Hendra Virus and Nipah Virus Infections……Page 615
    Postnatal Rubella……Page 616
    Chapter Summary……Page 618
    Review Questions……Page 619
    Properties of Coronaviruses……Page 622
    Coronavirus Infections in Humans……Page 623
    Review Questions……Page 626
    Rabies……Page 628
    Slow Virus Infections and Prion Diseases……Page 634
    Review Questions……Page 637
    General Features of Viral Carcinogenesis……Page 640
    Molecular Mechanisms of Carcinogenesis……Page 641
    Interactions of Tumor Viruses with Their Hosts……Page 642
    Retroviruses……Page 643
    DNA Tumor Viruses……Page 649
    Polyomaviruses……Page 650
    Papillomaviruses……Page 652
    Herpesviruses……Page 655
    Chapter Summary……Page 656
    Review Questions……Page 657
    Properties of Lentiviruses……Page 660
    HIV Infections in Humans……Page 664
    Chapter Summary……Page 674
    Review Questions……Page 675
    45. Medical Mycology……Page 678
    General Properties, Virulence, and Classification of Pathogenic Fungi……Page 679
    Laboratory Diagnosis of Mycoses……Page 683
    Cutaneous Mycoses……Page 686
    Subcutaneous Mycoses……Page 690
    Sporotrichosis……Page 691
    Chromoblastomycosis……Page 692
    Mycetoma……Page 694
    Endemic Mycoses……Page 695
    Coccidioidomycosis……Page 696
    Histoplasmosis……Page 700
    Blastomycosis……Page 703
    Paracoccidioidomycosis……Page 704
    Candidiasis……Page 705
    Cryptococcosis……Page 709
    Aspergillosis……Page 711
    Mucormycosis……Page 713
    Other Opportunistic Mycoses……Page 714
    Key Concepts: Opportunistic Mycoses……Page 715
    Mycotoxins……Page 716
    Antifungal Chemotherapies……Page 717
    46. Medical Parasitology……Page 726
    Classification of Parasites……Page 727
    Intestinal Protozoan Infections……Page 731
    Entamoeba histolytica (Intestinal and Tissue Ameba)……Page 732
    Cryptosporidium (Intestinal Sporozoa)……Page 734
    Blood Flagellates……Page 735
    Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense (Blood Flagellates)……Page 736
    Trypanosoma cruzi (Blood Flagellate)……Page 737
    Leishmania Species (Blood Flagellates)……Page 738
    Naegleria fowleri, Acanthamoeba castellanii, and Balamuthia mandrillaris (Free-Living Amebae)……Page 739
    Plasmodium Species (Blood Sporozoa)……Page 740
    Babesia microti (Blood Sporozoa)……Page 743
    Microsporidia……Page 744
    Intestinal Helminthic Infections……Page 745
    Trichuris trichiura (Whipworm—Intestinal Nematode)……Page 746
    Ascaris lumbricoides (Human Roundworm— Intestinal Nematode)……Page 750
    Ancylostoma duodenale and Necator americanus (Human Hookworms—Intestinal Nematode)……Page 751
    Trichinella spiralis (Intestinal and Tissue Nematode)……Page 752
    Taenia saginata (Beef Tapeworm—Intestinal Cestode) and Taenia solium (Pork Tapeworm— Intestinal and Tissue Cestode)……Page 753
    Wuchereria bancrofti, Brugia malayi, and Brugia timori (Lymphatic Filariasis—Tissue Nematodes)……Page 754
    Dracunculus medinensis (Guinea Worm—Tissue Nematode)……Page 755
    Larva migrans (Zoonotic Larval Nematode Infections)……Page 756
    Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium (Blood Flukes)……Page 757
    Echinococcus granulosus (Hydatid Cyst)……Page 758
    Review Questions……Page 759
    Communication Between Physician and Laboratory……Page 762
    Diagnosis of Bacterial and Fungal Infections……Page 763
    Key Concepts: Antifungal Chemotherapy……Page 721
    Review Questions……Page 722
    Laboratory Aids in the Selection of Antimicrobial Therapy……Page 774
    Diagnosis of Infection by Anatomic Site……Page 775
    Anaerobic Infections……Page 781
    Diagnosis of Chlamydial Infections……Page 782
    Diagnosis of Viral Infections……Page 783
    Review Questions……Page 788
    Central Nervous System……Page 792
    Respiratory……Page 796
    Heart……Page 801
    Abdomen……Page 802
    Urinary Tract……Page 804
    Bone and Soft Tissue……Page 809
    Sexually Transmitted Diseases……Page 811
    Mycobacterium tuberculosis Infections……Page 814
    Myocobacterium Avium Complex……Page 817
    Infections in Transplant Patients……Page 821
    Emerging Infections……Page 824

    Title: Jawetz, Melnick & Adelberg’s Medical Microbiology
    Author(s): Stefan Riedel, Stephen Morse, Timothy Mietzner, Steve Miller
    Publisher: McGraw-Hill
    Year: 2019 Edition: 28th Edition
    Language: English Pages (biblio\tech): 827\827
    ISBN: 9781260012026
    Size: 93 MB (97923768 bytes) Extension: pdf

     

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