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[PDF] Genomics and Proteomics Functional and Computational Aspects – Sándor Suhai

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Genomics and Proteomics Functional and Computational Aspects – Sándor Suhai

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About this book
Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.
Table of contents :
… and Counting….Pages 1-3
Obtaining and Evaluating Gene Expression Profiles with cDNA Microarrays….Pages 5-25
Large Scale Expression Screening Identifies Molecular Pathways and Predicts Gene function….Pages 27-35
The Glean Machine….Pages 37-49
Automatic Assembly and Editing of Genomic Data….Pages 51-65
Quest….Pages 67-82
An Essay on Individual Sequence Variation in Expressed Sequence Tags(ESTs)….Pages 83-94
Sequence Similarity Based Gene Prediction….Pages 95-106
Functional Proteomics….Pages 107-120
The Genome as a Flexible Polymer Chain….Pages 121-132
Analysis of Chromosome Territory Architecture in the Human Cell Nucleus….Pages 133-140
From Sequence to Structure and Function….Pages 141-148
Shox Homeobox Gene and Turner Syndrome….Pages 149-155
A Feature-Based Approach to Discrimination and Prediction of Protein Folding….Pages 157-177
Linking Structural Biology With Genome Research….Pages 179-189
G Protein-Coupled Receptors, or The Power of Data….Pages 191-214
Distributed Application Management in Bioinformatics….Pages 215-229
Is Human Genetics Becoming Dagerous to Society?….Pages 231-242

Genomics and Proteomics: Functional and Computational Aspects

Author(s): Jörg D. Hoheisel (auth.), Sándor Suhai (eds.)

Publisher: Springer US, Year: 2002

ISBN: 978-0-306-46312-9


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